In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
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چکیده
منابع مشابه
Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo.
The effects of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on human CYP3A activity were evaluated using midazolam (MDZ) as a phenotypic probe. Sixteen healthy volunteers were randomly assigned to receive either goldenseal or kava kava for 14 days. Each supplementation phase was followed by a 30-day washout period. MDZ (8 mg, per os) was administered befor...
متن کاملKava lactones and the kava-kava controversy.
Kava-kava is a traditional beverage of the South Pacific islanders and has had centuries of use without major side effects. Standardised extracts of kava-kava produced in Europe have led to many serious health problems and even to death. The extraction process (aqueous vs. acetone in the two types of preparations) is responsible for the difference in toxicity as extraction of glutathione in add...
متن کاملShort Communication INHIBITION OF HUMAN CYTOCHROME P450 ACTIVITIES BY KAVA EXTRACT AND KAVALACTONES
The herb kava has recently been associated with numerous drug interactions, but its interaction with cytochrome P450 (P450) enzymes has not been investigated. In the present work the inhibition of P450 enzymes by kava extract and individual kavalactones in human liver microsomes (HLMs) was investigated. Whole kava extract (normalized to 100 M total kavalactones) caused concentration-dependent d...
متن کاملShort Communication INHIBITION OF HUMAN CYTOCHROME P450 ACTIVITIES BY KAVA EXTRACT AND KAVALACTONES
The herb kava has recently been associated with numerous drug interactions, but its interaction with cytochrome P450 (P450) enzymes has not been investigated. In the present work the inhibition of P450 enzymes by kava extract and individual kavalactones in human liver microsomes (HLMs) was investigated. Whole kava extract (normalized to 100 M total kavalactones) caused concentration-dependent d...
متن کاملInhibition of human cytochrome P450 activities by kava extract and kavalactones.
The herb kava has recently been associated with numerous drug interactions, but its interaction with cytochrome P450 (P450) enzymes has not been investigated. In the present work the inhibition of P450 enzymes by kava extract and individual kavalactones in human liver microsomes (HLMs) was investigated. Whole kava extract (normalized to 100 microM total kavalactones) caused concentration-depend...
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ژورنال
عنوان ژورنال: Clinical Pharmacology & Therapeutics
سال: 2005
ISSN: 0009-9236
DOI: 10.1016/j.clpt.2005.01.009